Bronchodilator Secondary Metabolites from Rhazya stricta Decne Aerial Parts

The plant kingdom comprises medicinally useful plants that have provided many new drugs used to treat various diseases. In our search for bronchodilator secondary metabolites from growing in Saudi Arabia, the total extract of Rhazya stricta showed activity against carbamylcholine- (CCh) induced bronchoconstriction guinea pig tracheal muscles as an ex vivo model. fractions obtained liquid–liquid extraction process were tested effects. most active ethyl acetate fraction (RS-E) and aqueous (RS-H) subjected biologically guided phytochemical study using different stationary phases chromatographic techniques isolate pure metabolites. Five known compounds isolated fractions. Three alkaloids namely; (-)-quebrachamine (1), (+)-eburenine (2), (+)-stemmadenine (3) well two iridoid glycosides loganic acid (4) loganine (5) identified by spectroscopic methods. Among 1 5 only bronchodilators plant. It is worth mention are first time R. stricta.